Detection of microlesions induced by heavy ions using liposomes filled with fluorescent dye.

In cells irradiation by heavy ions has been hypothesized to produce microlesions, regions of local damage. In cell membranes this damage is thought to manifest itself in the form of holes. The primary evidence for microlesions comes from morphological studies of cell membranes, but this evidence is still controversial, especially since holes also have been observed in membranes of normal, nonirradiated, cells. However, it is possible that damage not associated with histologically discernable disruptions may still occur. In order to resolve this issue, we developed a system for detecting microlesions based on liposomes filled with fluorescent dye. We hypothesized that if microlesions form in these liposomes as the result of irradiation, then the entrapped dye will leak out into the surrounding medium in a measurable way. Polypropylene vials containing suspensions of vesicles composed of either dipalmitoyl phosphatidylcholine, or a combination of egg phosphatidylcholine and cholesterol were irradiated at the Brookhaven National Laboratory using 56Fe ions at 1 GeV/amu. In several cases we obtained a significant loss of the entrapped dye above the background level. Our results suggest that holes may form in liposomes as the result of heavy ion irradiation, and that these holes are large enough to allow leakage of cell internal contents that are at least as large as a 1 nm diameter calcein molecule.     

High energy-density propulsion—reducing the risk to humans in planetary exploration

The potential benefits to humankind of space exploration are tremendous. Space is not only the final frontier but is also the next marketplace. The orbital space above Earth offers tremendous opportunities for both strategic assets and commercial development. The critical obstacle retarding the use of the space around the Earth is the lack of low cost access to orbit. Further out, the next giant leap for mankind will be the human exploration of Mars. Almost certainly within the next 30 years, a human crew will brave the isolation, the radiation, and the lack of gravity to walk on and explore the Red planet. Both of these missions will change the outlook and perspective of every human being on the planet. However, these missions are expensive and extremely difficult. Chemical propulsion has demonstrated an inability to achieve orbit cheaply and is a very high-risk option to accomplish the Mars mission. An alternative solution is to develop a high performance propulsion system. Nuclear propulsion has the potential to be such a system. The question will be whether humanity is willing to take on the challenge.     

称重传感器的一种新的滞后补偿方法(英文)

通过对电阻应变式称重传感器在各种加载卸载情况下的滞后特性的分析 ,建立了其相应的数学模型 ,并初步探讨了一种可以通过程序在仪表中对传感器的重要指标—滞后进行补偿从而提高整个传感器的精度的方法。最后 ,对以上方法进行了验证性试验 ,证明了补偿方法的可行性。     

Effects of spaceflight (STS-87) on tropisms and plastid positioning in protonemata of the moss Ceratodon purpureus.

Apical cells of moss protonemata represent a single-celled system that perceives and reacts to light (positive and negative phototropism) and to gravity (negative gravitropism). Phototropism completely overrides gravitropism when apical cells are laterally irradiated with relatively high red light intensities, but below a defined light intensity threshold gravitropism competes with the phototropic reaction. A 16 day-long exposure to microgravity conditions demonstrated that gravitropism is allowed when protonemata are laterally illuminated with light intensities below 140 nmol m-2s-1. Protonemata that were grown in darkness in microgravity expressed an endogenous tendency to grow in arcs so that the overall culture morphology resembled a clockwise spiral. However this phenomenon only was observed in cultures that had reached a critical age and/or size. Organelle positioning in dark-grown apical cells was significantly altered in microgravity. Gravisensing most likely involves the sedimentation of starch-filled amyloplasts in a well-defined area of the tip cell. Amyloplasts that at 1-g are sedimented were clustered at the apical part of the sedimentation zone in microgravity. Clustering observed in microgravity or during clino-rotation significantly differs from sedimentation-induced plastid aggregations after inversion of tip cells at 1-g.     

The influence of dose, dose-rate and particle fragmentation on cataract induction by energetic iron ions.

Because activities in space necessarily involve chronic exposure to a heterogeneous charged particle radiation field it is important to assess the influence of dose-rate and the possible modulating role of heavy particle fragmentation on biological systems. Using the well-studied cataract model, mice were exposed to plateau 600 MeV/amu 56Fe ions either as acute or fractionated exposures at total doses of 5 - 504 cGy. Additional groups of mice received 20, 360 and 504 cGy behind 50 mm of polyethylene, which simulates body shielding. The reference radiation consisted of 60Co gamma radiation. The animals were examined by slit lamp biomicroscopy over their three year life spans. In accordance with our previous observations with heavy particles, the cataractogenic potential of the 600 MeV/amu 56Fe ions was greater than for low-LET radiation and increased with decreasing dose relative to gamma-rays. Fractionation of a given dose of 56Fe ions did not reduce the cataractogenicity of the radiation compared to the acute regimen. Fragmentation of the beam in the polyethylene did not alter the cataractotoxicity of the ions, either when administered singly or in fractions.     

VKM—5型立式捏合机研制与应用

介绍自行研制的VKM—5型立式捏合机的构造及工作原理,详述了该机采用液压传动和气动元件进行位置检测以及气、电、液安全联锁的特点,并说明与卧式捏合机对比试验情况。     

A method for improving extended Kalman filter performance forangle-only passive ranging

A relatively simple method is presented which eliminates previously reported (Oct. 1985) erratic estimation performance associated with Cartesian formulations of the extended Kalman filter (EKF) for the 2D angle-only emitter location problem. The technique is based on an initialization procedure which combines a priori probability density function (pdf) information with single measurement a posteriori pdf information in a manner which is more efficient than the EKF. Simulation results are presented which demonstrate the utility of the technique as compared with a previously offered modified gain EKF     

The Electron Beam Instrument (F6) on Freja

The Electron Beam Instrument (F6) onFreja is the first attempt to apply the electron drift technique in a region of large ambient magnetic fields. The paper describes the operational principles, the technical realization, and the difficulties encountered in the derivation of the electric fields.